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Drug-Induced Acute Liver Injury

MedGen UID:
772489
•Concept ID:
C3658290
•
Disease or Syndrome
Synonyms: Acute Liver Injury, Drug Induced; Acute Liver Injury, Drug-Induced; Drug Induced Acute Liver Injury; Liver Injury, Drug-Induced, Acute

Professional guidelines

PubMed

Consensus Guidelines: Best Practices for Detection, Assessment and Management of Suspected Acute Drug-Induced Liver Injury During Clinical Trials in Adults with Chronic Viral Hepatitis and Adults with Cirrhosis Secondary to Hepatitis B, C and Nonalcoholic Steatohepatitis.
Treem WR, Palmer M, Lonjon-Domanec I, Seekins D, Dimick-Santos L, Avigan MI, Marcinak JF, Dash A, Regev A, Maller E, Patwardhan M, Lewis JH, Rockey DC, Di Bisceglie AM, Freston JW, Andrade RJ, Chalasani N
Drug Saf 2021 Feb;44(2):133-165. Epub 2020 Nov 3 doi: 10.1007/s40264-020-01014-2. PMID: 33141341Free PMC Article
Consensus guidelines: best practices for detection, assessment and management of suspected acute drug-induced liver injury occurring during clinical trials in adults with chronic cholestatic liver disease.
Palmer M, Regev A, Lindor K, Avigan MI, Dimick-Santos L, Treem W, Marcinak JF, Lewis JH, Anania FA, Seekins D, Shneider BL, Chalasani N
Aliment Pharmacol Ther 2020 Jan;51(1):90-109. Epub 2019 Nov 25 doi: 10.1111/apt.15579. PMID: 31762074Free PMC Article
Consensus: guidelines: best practices for detection, assessment and management of suspected acute drug-induced liver injury during clinical trials in patients with nonalcoholic steatohepatitis.
Regev A, Palmer M, Avigan MI, Dimick-Santos L, Treem WR, Marcinak JF, Seekins D, Krishna G, Anania FA, Freston JW, Lewis JH, Sanyal AJ, Chalasani N
Aliment Pharmacol Ther 2019 Mar;49(6):702-713. Epub 2019 Feb 13 doi: 10.1111/apt.15153. PMID: 30761572Free PMC Article

Recent clinical studies

Etiology

Design Strategy of Fluorescent Probes for Live Drug-Induced Acute Liver Injury Imaging.
Cheng D, Xu W, Gong X, Yuan L, Zhang XB
Acc Chem Res 2021 Jan 19;54(2):403-415. Epub 2020 Dec 31 doi: 10.1021/acs.accounts.0c00646. PMID: 33382249
The role of alcohol consumption on acetaminophen induced liver injury: Implications from a mathematical model.
Ghosh A, Berger I, Remien CH, Mubayi A
J Theor Biol 2021 Jun 21;519:110559. Epub 2020 Dec 15 doi: 10.1016/j.jtbi.2020.110559. PMID: 33333080
Empirical assessment of case-based methods for identification of drugs associated with acute liver injury in the French National Healthcare System database (SNDS).
Thurin NH, Lassalle R, Schuemie M, Pénichon M, Gagne JJ, Rassen JA, Benichou J, Weill A, Blin P, Moore N, Droz-Perroteau C
Pharmacoepidemiol Drug Saf 2021 Mar;30(3):320-333. Epub 2020 Nov 19 doi: 10.1002/pds.5161. PMID: 33099844
Endoplasmic Reticulum Targeting Ratiometric Fluorescent Probe for Carboxylesterase 2 Detection in Drug-Induced Acute Liver Injury.
Tian X, Yan F, Zheng J, Cui X, Feng L, Li S, Jin L, James TD, Ma X
Anal Chem 2019 Dec 17;91(24):15840-15845. Epub 2019 Nov 25 doi: 10.1021/acs.analchem.9b04189. PMID: 31713417
Signal detection of potentially drug-induced acute liver injury in children using a multi-country healthcare database network.
Ferrajolo C, Coloma PM, Verhamme KM, Schuemie MJ, de Bie S, Gini R, Herings R, Mazzaglia G, Picelli G, Giaquinto C, Scotti L, Avillach P, Pedersen L, Rossi F, Capuano A, van der Lei J, Trifiró G, Sturkenboom MC; EU-ADR consortium
Drug Saf 2014 Feb;37(2):99-108. doi: 10.1007/s40264-013-0132-9. PMID: 24446276

Diagnosis

An Extracellular miRNA-Responsive Artificial Receptor via Dynamic DNA Nano-assembly for Biomarker-Driven Therapy.
He F, Wang M, Wang J, Wang HH, Nie Z
Angew Chem Int Ed Engl 2023 Aug 1;62(31):e202305227. Epub 2023 Jun 27 doi: 10.1002/anie.202305227. PMID: 37336759
A highly selective ratiometric molecular probe for imaging peroxynitrite during drug-induced acute liver injury.
Gong X, Cheng D, Li W, Shen Y, Peng R, Shi L, He L, Yuan L
J Mater Chem B 2021 Oct 13;9(39):8246-8252. doi: 10.1039/d1tb01534f. PMID: 34499075
Design Strategy of Fluorescent Probes for Live Drug-Induced Acute Liver Injury Imaging.
Cheng D, Xu W, Gong X, Yuan L, Zhang XB
Acc Chem Res 2021 Jan 19;54(2):403-415. Epub 2020 Dec 31 doi: 10.1021/acs.accounts.0c00646. PMID: 33382249
Critical role of OX40 in drug-induced acute liver injury.
Zhang C, Jin H, Wang Y, Li C, Zhao X, Li Y, Shi W, Tian Y, Xu H, Tian D, Liu K, Jia J, Sun G, Zhang D
Br J Pharmacol 2020 Jul;177(14):3183-3196. Epub 2020 Apr 5 doi: 10.1111/bph.15041. PMID: 32133635Free PMC Article
Noninvasive Imaging of Drug-Induced Liver Injury with (18)F-DFA PET.
Salas JR, Chen BY, Wong A, Duarte S, Angarita SAK, Lipshutz GS, Witte ON, Clark PM
J Nucl Med 2018 Aug;59(8):1308-1315. Epub 2018 Mar 1 doi: 10.2967/jnumed.117.206961. PMID: 29496991Free PMC Article

Therapy

The oral administration of Lacticaseibacillus casei Shirota alleviates acetaminophen-induced liver injury through accelerated acetaminophen metabolism via the liver-gut axis in mice.
Lv L, Ren S, Jiang H, Yan R, Chen W, Yan R, Dong J, Shao L, Yu Y
mSphere 2024 Jan 30;9(1):e0067223. Epub 2024 Jan 9 doi: 10.1128/msphere.00672-23. PMID: 38193757Free PMC Article
The role of alcohol consumption on acetaminophen induced liver injury: Implications from a mathematical model.
Ghosh A, Berger I, Remien CH, Mubayi A
J Theor Biol 2021 Jun 21;519:110559. Epub 2020 Dec 15 doi: 10.1016/j.jtbi.2020.110559. PMID: 33333080
Noninvasive Imaging of Drug-Induced Liver Injury with (18)F-DFA PET.
Salas JR, Chen BY, Wong A, Duarte S, Angarita SAK, Lipshutz GS, Witte ON, Clark PM
J Nucl Med 2018 Aug;59(8):1308-1315. Epub 2018 Mar 1 doi: 10.2967/jnumed.117.206961. PMID: 29496991Free PMC Article
Drug-Induced Acute Liver Injury Within 12 Hours After Fluvastatin Therapy.
Li L, Ma Y, Geng XB, Song YX, Tan Z, Shang XM, Zhao GY, Zhao BQ, Tian MR
Am J Ther 2016 Jan-Feb;23(1):e318-20. doi: 10.1097/MJT.0000000000000012. PMID: 24451297
Drug-induced acute liver injury mimicking autoimmune hepatitis after intake of dietary supplements containing glucosamine and chondroitin sulfate.
von Felden J, Montani M, Kessebohm K, Stickel F
Int J Clin Pharmacol Ther 2013 Mar;51(3):219-23. doi: 10.5414/CP201835. PMID: 23391366

Prognosis

Noninvasive Imaging of Drug-Induced Liver Injury with (18)F-DFA PET.
Salas JR, Chen BY, Wong A, Duarte S, Angarita SAK, Lipshutz GS, Witte ON, Clark PM
J Nucl Med 2018 Aug;59(8):1308-1315. Epub 2018 Mar 1 doi: 10.2967/jnumed.117.206961. PMID: 29496991Free PMC Article
Acute liver failure with concurrent bupropion and carbimazole therapy.
Khoo AL, Tham LS, Lee KH, Lim GK
Ann Pharmacother 2003 Feb;37(2):220-3. doi: 10.1177/106002800303700212. PMID: 12549952

Clinical prediction guides

The role of alcohol consumption on acetaminophen induced liver injury: Implications from a mathematical model.
Ghosh A, Berger I, Remien CH, Mubayi A
J Theor Biol 2021 Jun 21;519:110559. Epub 2020 Dec 15 doi: 10.1016/j.jtbi.2020.110559. PMID: 33333080
Noninvasive Imaging of Drug-Induced Liver Injury with (18)F-DFA PET.
Salas JR, Chen BY, Wong A, Duarte S, Angarita SAK, Lipshutz GS, Witte ON, Clark PM
J Nucl Med 2018 Aug;59(8):1308-1315. Epub 2018 Mar 1 doi: 10.2967/jnumed.117.206961. PMID: 29496991Free PMC Article

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